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The 7 deadliest pandemics in history

From the Plague of Justinian to COVID-19, the epidemics that hit humanity hardest.

  1. 1

    “Spanish” flu

    Pandemic · 1918 – 1920 · Worldwide

    An H1N1 virus spreads in three waves, carried by troop movements during the First World War.

    ≈ 50 million deaths

  2. 2

    The Black Death

    Pandemic · 1347 – 1351 · Europe, Asia, North Africa

    Carried from Central Asia along trade routes, bubonic plague (Yersinia pestis) reaches the Genoese trading post of Caffa, from where ships spread it across the Mediterranean in the autumn of 1347.

    ≈ 25 million deaths

  3. 3

    Plague of Justinian

    Pandemic · 541 – 549 (first wave) · Byzantine Empire

    The first plague pandemic attested with certainty: ancient DNA confirms Yersinia pestis.

    ≈ 15 million deaths

  4. 4

    COVID-19 pandemic

    Pandemic · December 2019 – May 2023 · Worldwide

    The SARS-CoV-2 coronavirus, identified in Wuhan at the end of 2019, spreads to every continent within weeks.

    ≈ 7 million deaths

  5. 5

    Asian flu

    Pandemic · 1957 – 1958 · Worldwide

    A new influenza virus, H2N2, emerges in southern China in early 1957.

    ≈ 1 million deaths

  6. 6

    Great Plague of Marseille

    Pandemic · May 1720 – 1722 · France

    The ship Grand-Saint-Antoine, back from the Levant with a contaminated cargo of silk, arrives in Marseille on 25 May 1720.

    ≈ 120,000 deaths

  7. 7

    West African Ebola epidemic

    Pandemic · 2014 – 2016 · West Africa

    The largest Ebola epidemic in history starts in a village in Guinea’s forest region, then reaches the capitals of three countries with fragile health systems.

    11,325 deaths

HIV/AIDS, which has killed more than 40 million people since the 1980s, smallpox and the cholera pandemics are not yet in the atlas. Ranking based on the disasters in the Mémoire du Globe atlas, using the most commonly accepted tolls. For older events, the figures are orders of magnitude.

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